Ontology highlight
ABSTRACT:
SUBMITTER: Schonberg DL
PROVIDER: S-EPMC4646058 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Cancer cell 20151001 4
Glioblastomas display hierarchies with self-renewing cancer stem-like cells (CSCs). RNA sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing upregulation of the iron transporter transferrin, the top differentially expressed gene compared with tissue-specific progenitors. Direct interrogation of iron uptake demonstrated that CSCs potently extract iron from the microenvironment more effectively than other tumor cells. Systematic interrogation of iron flux determined ...[more]