Incremental benefits of screening colonoscopy over sigmoidoscopy in average-risk populations: a model-driven analysis.

ABSTRACT:

Purpose

Screening colonoscopy and flexible sigmoidoscopy (FSG) reduce the risk of colorectal cancer (CRC), but the magnitude and duration of protection, particularly against right-sided cancer, remain uncertain. We computed the incremental benefit of colonoscopy over FSG using a validated mathematical model, which reflects colorectal neoplasia growth characteristics while allowing uncertainty in endoscopic detection and removal of adenomas.

Methods

We calibrated models of CRC incidence within a multistage clonal expansion framework to data from: (1) San Francisco-Oakland SEER registry (reference population) and (2) FSG long-term follow-up data from 50,757 individuals after a negative FSG in the Kaiser Permanente system. We compared the residual CRC risks after FSG with full-

SUBMITTER: Jeon J 

PROVIDER: S-EPMC4646080 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature