Early illness features associated with mortality in the juvenile idiopathic inflammatory myopathies.

ABSTRACT:

Objective

Because juvenile idiopathic inflammatory myopathies (IIMs) are potentially life-threatening systemic autoimmune diseases, we examined risk factors for juvenile IIM mortality.

Methods

Mortality status was available for 405 patients (329 with juvenile dermatomyositis [DM], 30 with juvenile polymyositis [PM], and 46 with juvenile connective tissue disease-associated myositis [CTM]) enrolled in nationwide protocols. Standardized mortality ratios (SMRs) were calculated using US population statistics. Cox regression analysis was used to assess univariable associations with mortality, and random survival forest (RSF) classification and Cox regression analysis were used for multivariable associations.

Results

Of 17 deaths (4.2% overall mortality), 8 (2.4%) were in j

SUBMITTER: Huber AM 

PROVIDER: S-EPMC4646219 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature