Dynamic Bayesian Network Modeling of the Interplay between EGFR and Hedgehog Signaling.

ABSTRACT: Aberrant activation of sonic Hegdehog (SHH) signaling has been found to disrupt cellular differentiation in many human cancers and to increase proliferation. The SHH pathway is known to cross-talk with EGFR dependent signaling. Recent studies experimentally addressed this interplay in Daoy cells, which are presumable a model system for medulloblastoma, a highly malignant brain tumor that predominately occurs in children. Currently ongoing are several clinical trials for different solid cancers, which are designed to validate the clinical benefits of targeting the SHH in combination with other pathways. This has motivated us to investigate interactions between EGFR and SHH dependent signaling in greater depth. To our knowledge, there is no mathematical model describing the interplay between

SUBMITTER: Frohlich H 

PROVIDER: S-EPMC4646463 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature