Circulating cell-free miRNAs as biomarker for triple-negative breast cancer.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast cancer in women globally. This subtype often has early and high recurrence rates resulting in poor survival, partially due to lack of targeted therapies. Therefore, there is an urgent need to identify TNBC-specific biomarkers for early diagnosis and treatment monitoring, and to develop more effective targeted therapy.

Methods

By using miRCURY LNA array platform, we compared the differential miRNA expressions in plasma of patient with TNBC (n=5) and non-TNBC (n=5), as well as healthy controls (n=5). Potential miRNAs were then validated in a large cohort of patients by real-time PCR.

Results

Ten putative miRNAs from the microarray data that differentially expressed between non-TNBC and hea

SUBMITTER: Shin VY 

PROVIDER: S-EPMC4647231 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature