Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer.

ABSTRACT:

Background

Host immunity has critical roles in tumour surveillance. Tertiary lymphoid organs (TLOs) are induced in various inflamed tissues. The aim of this study was to investigate the clinicopathological and pathobiological characteristics of tumour microenvironment in pancreatic ductal carcinoma (PDC) with TLOs.

Methods

We examined 534 PDCs to investigate the clinicopathological impact of TLOs and their association with tumour-infiltrating immune cells, the cytokine milieu, and tissue characteristics.

Results

There were two different localisations of PDC-associated TLOs, intratumoral and peritumoral. A better outcome was observed in patients with intratumoral TLOs, and this was independent of other survival factors. The PDC tissues with intratumoral TLOs showed sig

SUBMITTER: Hiraoka N 

PROVIDER: S-EPMC4647237 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature