PHF11 expression and cellular distribution is regulated by the Toll-Like Receptor 3 Ligand Polyinosinic:Polycytidylic Acid in HaCaT keratinocytes.

ABSTRACT:

Background

Inflammatory skin diseases such as atopic dermatitis and psoriasis represent a complex interaction between the skin and infiltrating immune cells, resulting in damage to the skin barrier and increased inflammation. Polymorphisms in PHF11 have been associated with dermatitis and allergy and PHF11 regulates the transcription of T-cell cytokines as well as class switching to IgE in activated B-cells. The importance of skin barrier homeostasis in the context of inflammatory skin diseases, together with reports identifying PHF11 as an interferon-induced gene, have led us to examine its role in the innate immune response of keratinocytes.

Results

We developed a cell culture model that allowed us to analyze the effects of the double-stranded RNA analogue poly(I:C) on a c

SUBMITTER: Muscat P 

PROVIDER: S-EPMC4647448 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature