Functional analysis and transcriptional output of the Gottingen minipig genome.

ABSTRACT:

Background

In the past decade the Göttingen minipig has gained increasing recognition as animal model in pharmaceutical and safety research because it recapitulates many aspects of human physiology and metabolism. Genome-based comparison of drug targets together with quantitative tissue expression analysis allows rational prediction of pharmacology and cross-reactivity of human drugs in animal models thereby improving drug attrition which is an important challenge in the process of drug development.

Results

Here we present a new chromosome level based version of the Göttingen minipig genome together with a comparative transcriptional analysis of tissues with pharmaceutical relevance as basis for translational research. We relied on mapping and assembly of WGS (whole-genome-s

SUBMITTER: Heckel T 

PROVIDER: S-EPMC4647470 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature