A considerable proportion of CRF01_AE strains in China originated from circulating intrasubtype recombinant forms (CIRF).

ABSTRACT:

Background

In this study, the prevalence of HIV-1 CRF01_AE intrasubtype recombinants in China is estimated and their contributions to the epidemic are explored.

Methods

Available HIV-1 complete genomes of CRF01_AE were retrieved from the HIV database. The two alignments were evaluated with RDP3. Recombinants were defined as cases in which the recombination signal was supported by at least 3 methods with P-values of ≤0.05 after Bonferroni correction for multiple comparisons implemented in RDP3. Phylogenetic analysis was performed to further investigate the role of intrasubtype recombinants in epidemics.

Results

Here, 124 out of the 339 sequences from around the world (36.6 %) showed significant evidence of recombination. Here, 84 of these recombinants were from China,

SUBMITTER: Jia L 

PROVIDER: S-EPMC4647519 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature