An analysis of the association between prostate cancer risk loci, PSA levels, disease aggressiveness and disease-specific mortality.

ABSTRACT:

Background

Genome-wide association studies have identified multiple single-nucleotide polymorphsims (SNPs) associated with prostate cancer (PCa). Although these SNPs have been clearly associated with disease risk, their relationship with clinical outcomes is less clear. Our aim was to assess the frequency of known PCa susceptibility alleles within a single institution ascertainment and to correlate risk alleles with disease-specific outcomes.

Methods

We genotyped 1354 individuals treated for localised PCa between June 1988 and December 2007. Blood samples were prospectively collected and de-identified before being genotyped and matched to phenotypic data. We investigated associations between 61 SNPs and disease-specific end points using multivariable analysis and also determ

SUBMITTER: Sullivan J 

PROVIDER: S-EPMC4647539 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature