Time-varying effect and long-term survival analysis in breast cancer patients treated with neoadjuvant chemotherapy.

ABSTRACT:

Background

Recent studies have indicated the prognostic value of tumour subtype and pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). However these results were reported after a short follow-up and using a standard Cox model which could be unsatisfactory for time-dependent factors. In the present study, we identified the prognostic factors for long-term outcome after NAC, considering that they could have an inconstant impact over time.

Methods

Prognostic factors from 956 consecutive breast cancer patients treated with NAC were identified and associated with long-term outcomes. We estimated survival by a time function multivariate Cox model regression and stratified by follow-up length.

Results

The prognostic value of tumour histological grade

SUBMITTER: Baulies S 

PROVIDER: S-EPMC4647542 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature