High leukocyte mitochondrial DNA content contributes to poor prognosis in glioma patients through its immunosuppressive effect.

ABSTRACT:

Background

Epidemiological studies have indicated significant associations of leukocyte mitochondrial DNA (mtDNA) copy number with risk of several malignancies, including glioma. However, whether mtDNA content can predict the clinical outcome of glioma patients has not been investigated.

Methods

The mtDNA content of peripheral blood leukocytes from 336 glioma patients was examined using a real-time PCR-based method. Kaplan-Meier curves and Cox proportional hazards regression model were used to examine the association of mtDNA content with overall survival (OS) and progression-free survival (PFS) of patients. To explore the potential mechanism, the immune phenotypes of peripheral blood mononuclear cells (PBMCs) and plasma concentrations of several cytokines from another 20 gl

SUBMITTER: Chen Y 

PROVIDER: S-EPMC4647544 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature