Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population.

ABSTRACT:

Background

Plasminogen activator inhibitor -2 (PAI-2) is an important molecular that plays a crucial role in vascular homeostasis and constitutes a critical response mechanism to cardiovascular injury, such as atherosclerosis, coronary artery disease (CAD).

Methods

The aim of the current study was to explore the association between the variants in PAI-2 gene and CAD and its prognoses. The three variants (rs8093048, rs9946657, rs9320032) of the PAI-2 gene were detected in 407 patients with CAD and 518 control subjects. All patients with CAD underwent one-year follow-up for major adverse cardiac events (MACE).

Results

The frequencies of the TT genotype and T allele of rs8093048 was significantly higher in CAD patients than that in control subjects (7.6% vs.3.5%, P = 0.0

SUBMITTER: Li X 

PROVIDER: S-EPMC4647573 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature