Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common form of dementia. AD has a multifactorial disease etiology and is currently untreatable. Multiple genes and molecular mechanisms have been implicated in AD, including ß-amyloid deposition in the brain, neurofibrillary tangle accumulation of hyper-phosphorylated Tau, synaptic failure, oxidative stress and inflammation. Relatively little is known about the role of the blood-brain barriers, especially the blood-cerebrospinal fluid barrier (BCSFB), in AD. The BCSFB is involved in cerebrospinal fluid (CSF) production, maintenance of brain homeostasis and neurodegenerative disorders.

Results

Using an Agilent platform with common reference design, we performed a large scale gene expression analysis and functional annotation of

SUBMITTER: Bergen AA 

PROVIDER: S-EPMC4647590 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature