Characteristics and spread to the native population of HIV-1 non-B subtypes in two European countries with high migration rate.

ABSTRACT:

Background

Non-B subtypes account for at least 50 % of HIV-1 infections diagnosed in Belgium and Luxembourg. They are considered to be acquired through heterosexual contacts and infect primarily individuals of foreign origin. Information on the extent to which non-B subtypes spread to the local population is incomplete.

Methods

Pol and env gene sequences were collected from 410 non-subtype B infections. Profound subtyping was performed using 5 subtyping tools and sequences of both pol and env. Demographic information, disease markers (viral load, CD4 count) and viral characteristics (co-receptor tropism) were compared between subtypes. Maximum likelihood phylogenetic trees were constructed and examined for clustering.

Results

The majority of non-B infections were diag

SUBMITTER: Dauwe K 

PROVIDER: S-EPMC4647655 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature