Major differential gene regulation in Coxiella burnetii between in vivo and in vitro cultivation models.

ABSTRACT:

Background

Coxiella burnetii is the causative agent of the zoonotic disease Q fever. As it is an intracellular pathogen, infection by C. burnetii requires adaptation to its eukaryotic host and intracellular environment. The recently developed cell-free medium also allows the bacteria to propagate without host cells, maintaining its infection potential. The adaptation to different hosts or extracellular environments has been assumed to involve genome-wide modulation of C. burnetii gene expression. However, little is currently known about these adaptation events which are critical for understanding the intracellular survival of C. burnetii.

Results

We studied C. burnetii genome-wide transcriptional patterns in vivo (mice spleen) and in cell and cell-free in vitro culture model

SUBMITTER: Kuley R 

PROVIDER: S-EPMC4647677 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature