Characterization of the relationship between dose and blood eosinophil response following subcutaneous administration of mepolizumab.

ABSTRACT:

Objective

Mepolizumab is a humanized IgG1 monoclonal antibody that blocks human IL-5 from binding to the IL-5 receptor, which is mainly expressed on eosinophils. Eosinophils are key cells in the inflammatory cascade of various diseases, including asthma. This study investigated the pharmacokinetic (PK)/pharmacodynamic (PD) relationship between exposure of mepolizumab subcutaneous (SC) administration and blood eosinophil reduction compared with intravenous (IV) administration in adult subjects with asthma.

Methods

In this multi-center, randomized, open-label, parallel-group, repeat-dose study, 70 adult subjects received one of four possible treatment regimens: mepolizumab 12.5, 125, or 250 mg SC or 75 mg IV. In addition to analyzing the dose and PK/PD relationship, absolute b

SUBMITTER: Pouliquen IJ 

PROVIDER: S-EPMC4647865 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature