Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study.

ABSTRACT:

Background

Although HDL cholesterol concentrations are strongly and inversely associated with risk of coronary heart disease, interventions that raise HDL cholesterol do not reduce risk of coronary heart disease. HDL cholesterol efflux capacity-a prototypical measure of HDL function-has been associated with coronary heart disease after adjusting for HDL cholesterol, but its effect on incident coronary heart disease risk is uncertain.

Methods

We measured cholesterol efflux capacity and assessed its relation with vascular risk factors and incident coronary heart disease events in a nested case-control sample from the prospective EPIC-Norfolk study of 25 639 individuals aged 40-79 years, assessed in 1993-97 and followed up to 2009. We quantified cholesterol efflux capacity in 1

SUBMITTER: Saleheen D 

PROVIDER: S-EPMC4648056 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature