VEGF Gene Polymorphisms are Associated with Risk of Tetralogy of Fallot.

ABSTRACT:

Background

The aim of this study was to investigate associations of 3 common polymorphisms in the VEGF gene, -2578C>A, -634C>G, and 936C>T, with risk of tetralogy of Fallot (TOF) in Chinese Han children.

Material and methods

From January 2010 to June 2013, a total of 400 pediatric subjects were recruited, including 160 cases with TOF (TOF group) and 240 healthy controls (control group). The genotypes of 3 common VEGF polymorphisms, -2578C>A, -634C>G, and 936C>T, were analyzed by polymerase chain reaction restriction fragment length polymorphism. All data were analyzed with SPSS 18.0 software.

Results

No significant differences were observed in body mass index or sex between TOF patients and controls (both P>0.05), but significant differences in age and family history

SUBMITTER: Li X 

PROVIDER: S-EPMC4648104 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature