Abnormal newborn screens and acylcarnitines in HIV-exposed and ARV-exposed infants.

ABSTRACT:

Background

Antiretroviral drugs (ARV), specifically nucleoside analogs, are toxic to mitochondrial oxidative phosphorylation. Other metabolic pathways, such as fatty acid oxidation, organic acid metabolism and amino acid metabolism, are dependent on normal oxidative phosphorylation but remain unexamined as potential points of ARV toxicity.

Methods

We analyzed newborn screening data from New York and compared proportions of abnormal newborn metabolic screens in HIV antibody screen-positive and HIV screen-negative neonates. Subsequently, we compared acylcarnitine levels in ARV-exposed (n = 16) and ARV-unexposed (n = 14) HIV-exposed infants to assess for dysfunctional fatty and organic acid metabolism.

Results

: The rate of abnormal newborn metabolic screens in HIV scree

SUBMITTER: Kirmse B 

PROVIDER: S-EPMC4648253 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature