Genetically determined height and coronary artery disease.

ABSTRACT:

Background

The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear.

Methods

We used a genetic approach to investigate the association between height and CAD, using 180 height-associated genetic variants. We tested the association between a change in genetically determined height of 1 SD (6.5 cm) with the risk of CAD in 65,066 cases and 128,383 controls. Using individual-level genotype data from 18,249 persons, we also examined the risk of CAD associated with the presence of various numbers of height-associated alleles. To identify putative mechanisms, we analyzed whether genetically determined height was associated with known cardiovascular risk factors and performed a pathway analysis of t

SUBMITTER: Nelson CP 

PROVIDER: S-EPMC4648271 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature