Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype.

ABSTRACT:

Background

Pediatric low-grade gliomas (PLGGs), the most frequent pediatric brain tumor, comprise a heterogeneous group of diseases. Recent genomic analyses suggest that these tumors are mostly driven by mitogene-activated protein kinase (MAPK) pathway alterations. However, little is known about the molecular characteristics inherent to their clinical and histological heterogeneity.

Methods

We performed gene expression profiling on 151 paraffin-embedded PLGGs from different locations, ages, and histologies. Using unsupervised and supervised analyses, we compared molecular features with age, location, histology, and BRAF genomic status. We compared molecular differences with normal pediatric brain expression profiles to observe whether those patterns were mirrored in normal b

SUBMITTER: Bergthold G 

PROVIDER: S-EPMC4648300 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature