PH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI.

ABSTRACT:

Background

Interstitial tissue acidosis resulting from abnormal perfusion and metabolism is a hallmark of cancer. The current study demonstrates that chemical exchange saturation transfer (CEST) MRI can be used as a noninvasive pH-weighted molecular imaging technique by targeting the chemical exchange between amine protons and protons in extracellular bulk water.

Methods

First, the sensitivity of amine CEST was validated in phantoms under a variety of conditions, including different magnetic field strengths, amino acid concentrations, and pH values. Amine CEST was compared with histology in both a preclinical GL261 intracranial glioma model at 7T and human patients at 3T. The association between physiologic and pH-weighted MRI was explored, along with the ability to predict

SUBMITTER: Harris RJ 

PROVIDER: S-EPMC4648305 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature