Dendritic spine dynamics leading to spine elimination after repeated inductions of LTD.

ABSTRACT: Memory is fixed solidly by repetition. However, the cellular mechanism underlying this repetition-dependent memory consolidation/reconsolidation remains unclear. In our previous study using stable slice cultures of the rodent hippocampus, we found long-lasting synaptic enhancement/suppression coupled with synapse formation/elimination after repeated inductions of chemical LTP/LTD, respectively. We proposed these phenomena as useful model systems for analyzing repetition-dependent memory consolidation. Recently, we analyzed the dynamics of dendritic spines during development of the enhancement, and found that the spines increased in number following characteristic stochastic processes. The current study investigates spine dynamics during the development of the suppression. We found that the

SUBMITTER: Hasegawa S 

PROVIDER: S-EPMC4648349 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature