RNA editing differently affects protein-coding genes in D. melanogaster and H. sapiens.

ABSTRACT: When an RNA editing event occurs within a coding sequence it can lead to a different encoded amino acid. The biological significance of these events remains an open question: they can modulate protein functionality, increase the complexity of transcriptomes or arise from a loose specificity of the involved enzymes. We analysed the editing events in coding regions that produce or not a change in the encoded amino acid (nonsynonymous and synonymous events, respectively) in D. melanogaster and in H. sapiens and compared them with the appropriate random models. Interestingly, our results show that the phenomenon has rather different characteristics in the two organisms. For example, we confirm the observation that editing events occur more frequently in non-coding than in coding regions, and r

SUBMITTER: Grassi L 

PROVIDER: S-EPMC4648400 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature