Leukotriene-receptor antagonists versus placebo in the treatment of asthma in adults and adolescents: a systematic review and meta-analysis.

ABSTRACT:

Background

Leukotriene-receptor antagonists (LTRAs) are recommended as an alternative treatment in patients with mild asthma, but their effect compared with placebo is unclear.

Purpose

To determine the benefits and harms of LTRAs as monotherapy or in combination with inhaled corticosteroids compared with placebo in adults and adolescents with asthma.

Data sources

MEDLINE and the Cochrane Central Register of Controlled Trials from inception through June 2015.

Study selection

Peer-reviewed, English-language, randomized, controlled trials in patients with asthma that reported the effect of LTRAs versus placebo on measures of asthma control.

Data extraction

Three researchers extracted data on study population, interventions, outcome measures, and adverse eve

SUBMITTER: Miligkos M 

PROVIDER: S-EPMC4648683 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature