Mitochondrial Regulation of the Muscle Microenvironment in Critical Limb Ischemia.

ABSTRACT: Critical limb ischemia (CLI) is the most severe clinical presentation of peripheral arterial disease and manifests as chronic limb pain at rest and/or tissue necrosis. Current clinical interventions are largely ineffective and therapeutic angiogenesis based trials have shown little efficacy, highlighting the dire need for new ideas and novel therapeutic approaches. Despite a decade of research related to skeletal muscle as a determinant of morbidity and mortality outcomes in CLI, very little progress has been made toward an effective therapy aimed directly at the muscle myopathies of this disease. Within the muscle cell, mitochondria are well positioned to modulate the ischemic cellular response, as they are the principal sites of cellular energy production and the major regulators of cell

SUBMITTER: Ryan TE 

PROVIDER: S-EPMC4649016 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature