A Winding Road: Alzheimer's Disease Increases Circuitous Functional Connectivity Pathways.

ABSTRACT: Neuroimaging has been successful in characterizing the pattern of cerebral atrophy that accompanies the progression of Alzheimer's disease (AD). Examination of functional connectivity, the strength of signal synchronicity between brain regions, has gathered pace as another way of understanding changes to the brain that are associated with AD. It appears to have good sensitivity and detect effects that precede cognitive decline, and thus offers the possibility to understand the neurobiology of the disease in its earliest phases. However, functional connectivity analyzes to date generally consider only the strongest connections, with weaker links ignored. This proof-of-concept study compared patients with mild-to-moderate AD (N = 11) and matched control individuals (N = 12) based on function

SUBMITTER: Suckling J 

PROVIDER: S-EPMC4649041 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature