Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway.

ABSTRACT: The number of stem/progenitor cells available can profoundly impact tissue homeostasis and the response to injury or disease. Here, we propose that an atypical PKC, Prkci, is a key player in regulating the switch from an expansion to a differentiation/maintenance phase via regulation of Notch, thus linking the polarity pathway with the control of stem cell self-renewal. Prkci is known to influence symmetric cell division in invertebrates; however a definitive role in mammals has not yet emerged. Using a genetic approach, we find that loss of Prkci results in a marked increase in the number of various stem/progenitor cells. The mechanism used likely involves inactivation and symmetric localization of NUMB, leading to the activation of NOTCH1 and its downstream effectors. Inhibition of atypi

SUBMITTER: Mah IK 

PROVIDER: S-EPMC4649379 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature