A Novel Statistical Model to Estimate Host Genetic Effects Affecting Disease Transmission.

ABSTRACT: There is increasing recognition that genetic diversity can affect the spread of diseases, potentially affecting plant and livestock disease control as well as the emergence of human disease outbreaks. Nevertheless, even though computational tools can guide the control of infectious diseases, few epidemiological models can simultaneously accommodate the inherent individual heterogeneity in multiple infectious disease traits influencing disease transmission, such as the frequently modeled propensity to become infected and infectivity, which describes the host ability to transmit the infection to susceptible individuals. Furthermore, current quantitative genetic models fail to fully capture the heritable variation in host infectivity, mainly because they cannot accommodate the nonlinear infec

SUBMITTER: Anacleto O 

PROVIDER: S-EPMC4649657 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature