Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years.

ABSTRACT:

Background

The relationship between sensitization to allergens and disease is complex.

Objective

We sought to identify patterns of response to a broad range of allergen components and investigate associations with asthma, eczema, and hay fever.

Methods

Serum specific IgE levels to 112 allergen components were measured by using a multiplex array (Immuno Solid-phase Allergen Chip) in a population-based birth cohort. Latent variable modeling was used to identify underlying patterns of component-specific IgE responses; these patterns were then related to asthma, eczema, and hay fever.

Results

Two hundred twenty-one of 461 children had IgE to 1 or more components. Seventy-one of the 112 components were recognized by 3 or more children. By using latent variable model

SUBMITTER: Simpson A 

PROVIDER: S-EPMC4649774 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature