Unraveling the molecular architecture of a G protein-coupled receptor/β-arrestin/Erk module complex.

ABSTRACT: β-arrestins serve as signaling scaffolds downstream of G protein-coupled receptors, and thus play a crucial role in a plethora of cellular processes. Although it is largely accepted that the ability of β-arrestins to interact simultaneously with many protein partners is key in G protein-independent signaling of GPCRs, only the precise knowledge of these multimeric arrangements will allow a full understanding of the dynamics of these interactions and their functional consequences. However, current experimental procedures for the determination of the three-dimensional structures of protein-protein complexes are not well adapted to analyze these short-lived, multi-component assemblies. We propose a model of the receptor/β-arrestin/Erk1 signaling module, which is consistent with most of the av

SUBMITTER: Bourquard T 

PROVIDER: S-EPMC4649906 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature