Mining for novel candidate clock genes in the circadian regulatory network.

ABSTRACT:

Background

Most physiological processes in mammals are temporally regulated by means of a master circadian clock in the brain and peripheral oscillators in most other tissues. A transcriptional-translation feedback network of clock genes produces near 24 h oscillations in clock gene and protein expression. Here, we aim to identify novel additions to the clock network using a meta-analysis of public chromatin immunoprecipitation sequencing (ChIP-seq), proteomics and protein-protein interaction data starting from a published list of 1000 genes with robust transcriptional rhythms and circadian phenotypes of knockdowns.

Results

We identified 20 candidate genes including nine known clock genes that received significantly high scores and were also robust to the relative weights as

SUBMITTER: Bhargava A 

PROVIDER: S-EPMC4650315 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature