Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression.

ABSTRACT: Disturbed cell autophagy is found in various cardiovascular disease conditions. Biomechanical stimuli induced by laminar blood flow have important protective actions against the development of various vascular diseases. However, the impacts and underlying mechanisms of shear stress on the autophagic process in vascular endothelial cells (ECs) are not entirely understood. Here we investigated the impacts of shear stress on autophagy in human vascular ECs. We found that shear stress induced by laminar flow, but not that by oscillatory or low-magnitude flow, promoted autophagy. Time-course analysis and flow cessation experiments confirmed that this effect was not a transient adaptive stress response but appeared to be a sustained physiological action. Flow had no effect on the mammalian targe

SUBMITTER: Liu J 

PROVIDER: S-EPMC4650738 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature