Intracellular bacteria in the pathogenesis of Escherichia coli urinary tract infection in children.

ABSTRACT:

Background

Uropathogenic Escherichia coli (UPEC) is the most common agent of urinary tract infection (UTI). The classic model of pathogenesis proposes the ascent of UPEC by the urethra and external adherence to the urothelium. Recently, the ability of UPEC to invade urothelial cells and to form intracellular bacterial communities (IBCs) has been described.

Methods

The objective of the present study was to determine the presence of intracellular bacteria (IB) in children with UTI caused by E. coli and to characterize its virulence attributes and its relation with clinical outcomes. One hundred thirty-three children with E. coli UTI who attended a reference children's hospital between June and November 2012 were included. Urine samples were analyzed by optical and confocal mic

SUBMITTER: Robino L 

PROVIDER: S-EPMC4650771 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature