GenomicInteractions: An R/Bioconductor package for manipulating and investigating chromatin interaction data.

ABSTRACT:

Background

Precise quantitative and spatiotemporal control of gene expression is necessary to ensure proper cellular differentiation and the maintenance of homeostasis. The relationship between gene expression and the spatial organisation of chromatin is highly complex, interdependent and not completely understood. The development of experimental techniques to interrogate both the higher-order structure of chromatin and the interactions between regulatory elements has recently lead to important insights on how gene expression is controlled. The ability to gain these and future insights is critically dependent on computational tools for the analysis and visualisation of data produced by these techniques.

Results and conclusion

We have developed GenomicInteractions, a freely a

SUBMITTER: Harmston N 

PROVIDER: S-EPMC4650858 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature