Pressure Pain Sensitivity in Patients With Suspected Opioid-Induced Hyperalgesia.

ABSTRACT:

Background and objectives

This study was designed to test whether a brief quantitative sensory testing assessment could be used to detect hyperalgesia in patients with suspected opioid-induced hyperalgesia (OIH).

Methods

Twenty patients on long-term opioid therapy with suspected OIH were recruited along with 20 healthy controls. Pressure pain threshold, Pain50, a measure of intermediate suprathreshold pressure pain sensitivity, and tolerance levels were evaluated. As a secondary outcome, changes in pressure pain sensitivity after intravenous administration of placebo (saline) and fentanyl (1.5 μg/kg) were assessed.

Results

There were no significant differences in pain measures between healthy controls and patients. However, there was an association between higher dose

SUBMITTER: Wasserman RA 

PROVIDER: S-EPMC4650890 | biostudies-literature | 2015 Nov-Dec

REPOSITORIES: biostudies-literature