Ontology highlight
ABSTRACT:
SUBMITTER: Crawford B
PROVIDER: S-EPMC4650998 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Crawford Bredon B Ozelo Margareth C MC Ogiwara Kenichi K Ahlin James J Albanez Silvia S Hegadorn Carol C Harpell Lori L Hough Christine C Lillicrap David D
Molecular therapy. Methods & clinical development 20151118
Recombinant FVIII manufacturing is characterized by poor product stability and low yields. Codon-optimization of transgenes accelerates translation by exploiting the synonymous codon usage bias of a species. However, this can alter the performance of the final product. Additionally, the effects of transgene design across diverse cell types are not well understood and are of interest for next-generation protein and gene therapies. To investigate the effects of transgene design across different ho ...[more]