A decision support framework for genomically informed investigational cancer therapy.

ABSTRACT: Rapidly improving understanding of molecular oncology, emerging novel therapeutics, and increasingly available and affordable next-generation sequencing have created an opportunity for delivering genomically informed personalized cancer therapy. However, to implement genomically informed therapy requires that a clinician interpret the patient's molecular profile, including molecular characterization of the tumor and the patient's germline DNA. In this Commentary, we review existing data and tools for precision oncology and present a framework for reviewing the available biomedical literature on therapeutic implications of genomic alterations. Genomic alterations, including mutations, insertions/deletions, fusions, and copy number changes, need to be curated in terms of the likelihood that

SUBMITTER: Meric-Bernstam F 

PROVIDER: S-EPMC4651038 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature