Global transcriptome and mutagenic analyses of the acid tolerance response of Salmonella enterica serovar Typhimurium.

ABSTRACT: Salmonella enterica serovar Typhimurium (S. Typhimurium) is one of the leading causative agents of food-borne bacterial gastroenteritis. Swift invasion through the intestinal tract and successful establishment in systemic organs are associated with the adaptability of S. Typhimurium to different stress environments. Low-pH stress serves as one of the first lines of defense in mammalian hosts, which S. Typhimurium must efficiently overcome to establish an infection. Therefore, a better understanding of the molecular mechanisms underlying the adaptability of S. Typhimurium to acid stress is highly relevant. In this study, we have performed a transcriptome analysis of S. Typhimurium under the acid tolerance response (ATR) and found a large number of genes (∼47%) to be differentially expressed

SUBMITTER: Ryan D 

PROVIDER: S-EPMC4651094 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature