Postmenopausal mammographic breast density and subsequent breast cancer risk according to selected tissue markers.

ABSTRACT: BACKGROUND:This study aimed to determine if associations of pre-diagnostic percent breast density, absolute dense area, and non-dense area with subsequent breast cancer risk differ by the tumour's molecular marker status. METHODS:We included 1010 postmenopausal women with breast cancer and 2077 matched controls from the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHS II) cohorts. Breast density was estimated from digitised film mammograms using computer-assisted thresholding techniques. Information on breast cancer risk factors was obtained prospectively from biennial questionnaires. Polychotomous logistic regression was used to assess associations of breast density measures with tumour subtypes by the status of selected tissue markers. All tests of statistical significance

SUBMITTER: Yaghjyan L 

PROVIDER: S-EPMC4651128 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature