The Genome Sequence of Saccharomyces eubayanus and the Domestication of Lager-Brewing Yeasts.

ABSTRACT: The dramatic phenotypic changes that occur in organisms during domestication leave indelible imprints on their genomes. Although many domesticated plants and animals have been systematically compared with their wild genetic stocks, the molecular and genomic processes underlying fungal domestication have received less attention. Here, we present a nearly complete genome assembly for the recently described yeast species Saccharomyces eubayanus and compare it to the genomes of multiple domesticated alloploid hybrids of S. eubayanus × S. cerevisiae (S. pastorianus syn. S. carlsbergensis), which are used to brew lager-style beers. We find that the S. eubayanus subgenomes of lager-brewing yeasts have experienced increased rates of evolution since hybridization, and that certain genes involved in

SUBMITTER: Baker E 

PROVIDER: S-EPMC4651232 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature