MicroRNA Regulatory Network Revealing the Mechanism of Inflammation in Atrial Fibrillation.

ABSTRACT:

Background

Atrial fibrillation (AF) is a highly prevalent condition associated with high morbidity and mortality that can cause or exacerbate heart failure and is an important risk factor for stroke. AF is the disorganized propagation of electrical activity in the atrium, which prevents organized contractions. However, the effect of microRNAs and the patterns of the regulatory network of AF remain vague.

Material and methods

The mRNA expression data of atrial tissue splices from 3 conditions - permanent atrial fibrillation (AF), sinus rhythm (SR), and human left ventricular non-failing myocardium (LV) - were downloaded from GSE2240 and the differentially expressed genes (DEGs) between the 3 kinds of samples were calculated. Then we constructed 3 miRNA-DEGs networks and these

SUBMITTER: Zhang H 

PROVIDER: S-EPMC4651320 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature