Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease.

ABSTRACT:

Background

Galectin-3, a β-galactoside binding lectin, has been described as a mediator of cardiac fibrosis in experimental studies and as a risk factor associated with cardiovascular events in subjects with heart failure. Previous studies have evaluated the genetic susceptibility to Chagas disease in humans, including the polymorphisms of cytokine genes, demonstrating correlations between the genetic polymorphism and cardiomyopathy development in the chronic phase. However, the relationship between the galectin-3 single nucleotide polymorphism (SNP) and phenotypic variations in Chagas disease has not been evaluated.

Objective

The present study aimed to determine whether genetic polymorphisms of galectin-3 may predispose to the development of cardiac forms of Chagas disease.

SUBMITTER: Cruz Gda S 

PROVIDER: S-EPMC4651405 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature