Screening Analogs of β-OG Pocket Binder as Fusion Inhibitor of Dengue Virus 2.

ABSTRACT: Dengue is an infectious disease caused by dengue virus (DENV) and transmitted between human hosts by mosquitoes. Recently, Indonesia was listed as a country with the highest cases of dengue by the Association of Southeast Asian Nations. The current treatment for dengue disease is supportive therapy; there is no antiviral drug available in the market against dengue. Therefore, a research on antiviral drug against dengue is very important, especially to prevent outbreak explosion. In this research, the development of dengue antiviral is performed through the inhibition of n-octyl-β-D-glucoside (β-OG) binding pocket on envelope protein of DENV by using analogs of β-OG pocket binder. There are 828 compounds used in this study, and all of them were screened based on the analysis of molecular do

SUBMITTER: Tambunan US 

PROVIDER: S-EPMC4651419 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature