Subject Based Registration for Individualized Analysis of Diffusion Tensor MRI.

ABSTRACT: Registration of subject and control brains to a common anatomical space or template is the basis for quantitatively delineating regions of abnormality in an individual brain. Normally, a brain atlas is chosen as the template. Limitations in the registration process result in persistent differences between individual subject brains and template, which can be a source of error in an analysis. We propose a new approach to the registration process where the subject of interest is the registration template. Through this change, we eliminate errors due to differences between a brain template and a subject's brain. We applied this method to the analysis of FA values derived from DTI data of 20 individual mTBI patients as compared to 48 healthy controls. Subject-centered analysis resulted in ident

SUBMITTER: Suri AK 

PROVIDER: S-EPMC4651497 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature