Predicting the integration of overlapping memories by decoding mnemonic processing states during learning.

ABSTRACT: The hippocampal memory system is thought to alternate between two opposing processing states: encoding and retrieval. When present experience overlaps with past experience, this creates a potential tradeoff between encoding the present and retrieving the past. This tradeoff may be resolved by memory integration-that is, by forming a mnemonic representation that links present experience with overlapping past experience. Here, we used fMRI decoding analyses to predict when - and establish how - past and present experiences become integrated in memory. In an initial experiment, we alternately instructed subjects to adopt encoding, retrieval or integration states during overlapping learning. We then trained across-subject pattern classifiers to 'read out' the instructed processing states from

SUBMITTER: Richter FR 

PROVIDER: S-EPMC4651766 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature