Smoking and schizophrenia in population cohorts of Swedish women and men: a prospective co-relative control study.

ABSTRACT:

Objective

The purpose of this study was to clarify the causes of the smoking-schizophrenia association.

Method

Using Cox proportional hazard and co-relative control models, the authors predicted future risk for a diagnosis of schizophrenia or nonaffective psychosis from the smoking status of 1,413,849 women and 233,879 men from, respectively, the Swedish birth and conscript registries.

Results

Smoking was assessed in women at a mean age of 27 and in men at a mean age of 18. The mean age at end of follow-up was 46 for women and 26 for men. Hazard ratios for first-onset schizophrenia were elevated both for light smoking (2.21 [95% CI=1.90-2.56] for women and 2.15 [95% CI=1.25-3.44] for men) and heavy smoking (3.45 [95% CI=2.95-4.03] for women and 3.80 [95% CI=1.19-6.60]

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC4651774 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature