Demarcation of secondary hyperalgesia zones: Punctate stimulation pressure matters.

ABSTRACT:

Background

Secondary hyperalgesia is increased sensitivity in normal tissue near an injury, and it is a measure of central sensitization reflecting injury-related effects on the CNS. Secondary hyperalgesia areas (SHAs), usually assessed by polyamide monofilaments, are important outcomes in studies of analgesic drug effects in humans. However, since the methods applied in demarcating the secondary hyperalgesia zone seem inconsistent across studies, we examined the effect of a standardized approach upon the measurement of SHA following a first degree burn injury (BI).

New method

The study was a two-observer, test-retest study with the two sessions separated by 6wk. An observer-blinded design adjusted to examine day-to-day and observer-to-observer variability in SHA was used. I

SUBMITTER: Ringsted TK 

PROVIDER: S-EPMC4651781 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature