Correlation between polymorphisms in the MFN1 gene and myopia in Chinese population.

ABSTRACT:

Aim

To explore whether genetic variations in the MFN1 gene are associated with low to moderate myopia in Chinese population.

Methods

The case-control association analysis was used. The study included 100 independent myopia patients (-0.75 D ≤ spherical refraction ≤-8.00 D) and 100 sex-matched healthy controls (with binocular spherical equivalent ranges between -0.50 D and +0.50 D). Four single nucleotide polymorphism (SNP) tags (rs3976523, rs13098637, rs6762399 and rs7618348) were selected for genotyping by direct sequencing. The frequencies of genotypes and their alleles were calculated based on the number of SNP genotypes in each sample. The Chi-square test was used to examine the difference in the frequency between the myopia cases and controls.

Results

Genotype di

SUBMITTER: Zou YC 

PROVIDER: S-EPMC4651875 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature